Black Tea-Induced Cellular Survival: Evidence for Reduced Toxicity and Enhanced Immunity in Mice Under Stress

  • Arindam Bhattacharyya Bose Institute, P-1/12 CIT Scheme VII M, Kolkata-700 054, India
  • Gaurisankar Sa Bose Institute, P-1/12 CIT Scheme VII M, Kolkata-700 054, India
  • Tanya Das Bose Institute, P-1/12 CIT Scheme VII M, Kolkata-700 054, India
  • Maqsood Siddiqi Bose Institute, P-1/12 CIT Scheme VII M, Kolkata-700 054, India

Abstract

It is known that during disease conditions like cancer, due to the disease itself or due to continuous exposure to various toxic drugs, the intrinsic regulatory machinery, e.g., immune and detoxification systems, of the host becomes jeopardized. Thus the drug has to be withdrawn to prevent further immunosuppression and toxicity in tumor-bearer, resulting in total failure of the treatment. It is, therefore, of utmost necessity to search for a biological response modifier that can restore the immunopharmacological balance of the host. Many dietary constituents are chemopreventive in animal models. It is already recognized that black tea, the popular beverage, has both anticancer and immunostimultory effects. In the current study the role of black tea in reducing toxicity and ameliorating immunosuppression in mice bearing Ehrlichs Ascites carcinoma (EAC) has been elaborated. Our results showed that black tea delivers the immune system of the host from its suppressed condition as caused by the developing tumor. It has also been demonstrated that this popular beverage is not toxic by itself, additionally it regresses the tumor-induced toxicity in the host and improves the blood parameters. All these findings indicate that black tea plays an important role in protecting the intrinsic defense machineries of the tumor bearer. These results may help in increasing the likelihood of success in chemoprevention trials and in providing dietary advice to the general population to ultimately optimize the chances of preventing cancer.
Keywords: Cancer; toxicity; immunity; mice; tumor bearer dietary constituents; immuno-stimulation; chemopreveion.

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How to Cite
Bhattacharyya, A., G. Sa, T. Das, and M. Siddiqi. “Black Tea-Induced Cellular Survival: Evidence for Reduced Toxicity and Enhanced Immunity in Mice Under Stress”. International Journal of Tea Science, Vol. 2, no. 01 and 02, June 2003, pp. 34-39, doi:10.20425/ijts.v2i1and2.4587.