Green Tea and its polyphenols, targeting signalling pathways for chemoprevention

Abstract

Tea polyphenols can protect against the multi-stages of cancer initiation, promotion, and progression. Research findings and epidemiologic studies suggest that the polyphenolic compounds, (-)-epigallocatechin-3-gallate (EGCG), (-)-epicatechin-3-gallate (ECG); (-)-epigallocatechin (EGC) and (-)-epicatechin (EC) found primarily in Green Tea have chemo-preventive potential. Cell signalling cascades and their interacting factors have become important targets of chemoprevention and phenolic phytochemicals and plant extracts seem to be promising in this endeavour.